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KMID : 0854720110310020077
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Korean Journal of Asthma, Allergy and Clinical Immunology
2011 Volume.31 No. 2 p.77 ~ p.83
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Drug Hypersensitivity Syndrome: A Literature Review of Associated Viral Reactivation
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Song Woo-Jung
Chang Yoon-Seok
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Abstract
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Drug hypersensitivity syndrome is a severe adverse drug reaction characterized by skin eruption and systemic manifestations, such as fever, eosinophilia, lymph node enlargement, hepatitis and renal dysfunction. The pathogenic mechanism of this syndrome is considered multifactorial but still remains to be elucidated. An interesting point is a possible association between drug reaction and herpesvirus reactivation. Since the first case reported by Descamps et al in 1997, there have been scores of reported cases suggesting this association, also being supported by clinical observation of flare-up of disease during the recovery phase. The purpose of this review is to describe its clinical characteristics and to evaluate the possibility of drug and viral interactions in the development of this syndrome through a literature review.
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KEYWORD
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Drug hypersensitivity, Drug eruptions, Herpesvirus 6, human, Virus activation
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